Description
Product Characteristics:
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Subcellular location: Cytoplasm
Synonyms: dynein, cytoplasmic, intermediate polypeptide 1, cytoplasmic dynein 1 intermediate chain 1, DH IC-1, dynein intermediate chain 1, cytosolic, cytoplasmic dynein intermediate chain 1, DC1I1_HUMAN, DYNC1I1, DNCI1, DNCIC1, Dynein cytoplasmic intermediate polypeptide 1.
Target Information: accessory subunit polypeptide to axonemal dyneins that may be involved in subcellular targeting [RGD, Feb 2006]